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{"1":{"1":{"inhalt":"Overview","key":"h1"}},"2":{"1":{"inhalt":"%26lt%3Bp+style%3D%26quot%3Bcolor%3A%23444%26quot%3B%26gt%3BToPAG+%28Toxic+Protein+AGgregation+in+Neurodegeneration%29+is+a+new+six-year+interdisciplinary+research+project+funded+by+the+EU+and+carried+out+by+two+Max+Planck+Institutes.+ToPAG%26amp%3Brsquo%3Bs+central+focus+is+neurodegeneration%2C+the+progressive+loss+of+structure+and+function+of+nerve+cells+%28neurons%29.+Neurodegeneration+eventually+results+in+neuronal+death%2C+either+of+motor+neurons+leading+to+motor+impairment+or+in+central+neurons+leading+to+dementia.+More+than+40+million+people+worldwide+live+with+dementia%2C+a+neurological+syndrome+which+affects+memory%2C+thinking+and+the+ability+to+perform+everyday+life+activities.+By+2050%2C+this+number+is+expected+to+triple.+Without+effective+treatments%26amp%3Bhellip%3B%26amp%3Bnbsp%3B%26lt%3B%2Fp%26gt%3B%0D%0A","key":"p_editor"}},"3":{"1":{"inhalt":"270","key":"floatboxstart"},"2":{"inhalt":"10","key":"floatboxstart"},"3":{"inhalt":"right","key":"floatboxstart"},"4":{"inhalt":"1","key":"floatboxstart"}},"4":{"1":{"inhalt":"%26lt%3Bp%26gt%3B%26lt%3Ba+href%3D%26quot%3B%2Fcmediacenter%2Fcimages%2Foverview%2Foverview_cr.jpg%26quot%3B+rel%3D%26quot%3Blightbox%26quot%3B%26gt%3B%26lt%3Bimg+alt%3D%26quot%3Boverview_cr%26quot%3B+src%3D%26quot%3B%2Fcmediacenter%2Fcimages%2Foverview%2Foverview_cr.jpg%26quot%3B+%2F%26gt%3B%26lt%3B%2Fa%26gt%3B%26lt%3B%2Fp%26gt%3B%0D%0A%0D%0A%26lt%3Bp%26gt%3B%26lt%3Bsmall%26gt%3BA+human+cell+line+expressing+an+aggregating+protein+%28green%29.+Aggregates+of+different+shapes+are+visible+in+many+cells.%26amp%3Bnbsp%3BCell+nuclei+are+labeled+in+blue.%26lt%3B%2Fsmall%26gt%3B%26lt%3B%2Fp%26gt%3B%0D%0A","key":"p_editor"}},"5":{"1":{"inhalt":"1","key":"floatboxend"}},"6":{"1":{"inhalt":"75","key":"floatboxstart"},"2":{"inhalt":"","key":"floatboxstart"},"3":{"inhalt":"left","key":"floatboxstart"},"4":{"inhalt":"2","key":"floatboxstart"}},"7":{"1":{"inhalt":"%E2%80%A6especially+the+industrial+countries+and+their+aging+populations+will+face+tremendous+medical+and+socio-economic+difficulties.+Dementia+is+predominantly+caused+by+different+neurodegenerative+diseases+such+as+Alzheimer%E2%80%99s+or+Huntington%E2%80%99s+disease.+Although+the+symptoms+of+neurodegenerative+diseases+may+vary%2C+many+of+them+have+one+observable+feature+in+common%3A+the+accumulation+of+misfolded+proteins+inside+or+outside+of+neurons+%28i.e.+aggregates%29.%0D%0AIn+order+to+better+understand+the+formation+and+effects+of+these+toxic+protein+aggregates%2C+four+leading+scientists+from+the+Max+Planck+Institutes+of+Biochemistry+and+Neurobiology+in+Martinsried+near+Munich%2C+Germany%2C+have+endeavored+on+a+pioneering+journey+to+address+this+challenge.++They+focus+on+the+basic+cellular+mechanisms+of+protein+aggregate+toxicity+and+establish+mouse+models+to+elucidate+the+role+of+protein+aggregates+in+neurodegeneration+from+several+different+angles+using+complimentary+methods.+","key":"p"}},"8":{"1":{"inhalt":"1","key":"floatboxend"}},"9":{"1":{"inhalt":"%E2%80%9CBy+identifying+potential+drug+targets%2C+this+information+may+serve+as+the+basis+for+developing+urgently+needed+therapies+that+can+halt+or+reverse+disease+processes+of+neurodegeneration%E2%80%9D%2C+says+Prof.+Hartl%2C+the+lead+investigator+of+the+ToPAG+project.","key":"p"}},"10":{"1":{"inhalt":"1","key":"floatboxclear"}}}